7.10.2026

Review of biochemistry. Structure and function of bioorganic compounds.

Required lecture:

Harpers Illustrated Biochemistry chapters:

Amino Acids & Peptides (3)

Carbohydrates of Physiologic Significance (13)

Lipids of Physiologic Significance (14)

Denise R. Ferrier "Biochemistry” chapters:

Amino Acids (1)

Structure of proteins (2)

Introduction to Carbohydrates (7)

14.10.2026

Proteins

Required lecture:

Harpers Illustrated Biochemistry chapters:

• Section 1 – Structures & Functions of Proteins & Enzymes – chapters 3-5.
• Section 5 – Biochemistry of Extracellular & Intracellular Communication – chapter 40 – Membranes: Structure & Function
• Section 6 – chapters 47 – Glycoproteins, 48 – The extracellular Matrix

Denise R. Ferrier "Biochemistry”:

• Chapters 1-4 - Amino Acids, Structure of Proteins, Globular Proteins, Fibrous Proteins – collagens and elastin metabolism, the role of markers in clinical diagnostics.

Post-translational modifications of proteins (discussed on lecture and seminar):

• Phosphorylation/dephosphorylation, Limited proteolysis, Ubiquitination, Methylation, Acetylation, Lipid modifications (prenylation, myristoylation, palmitoylation), Glycosylation, Nitrosylation, Hydroxylation, γ-carboxylation, Deamination

21.10.2026

Enzymes and coenzymes

Required lecture:

Denise R. Ferrier "Biochemistry” chapters:

Enzymes (5)

Bioenergetics and Oxidative Phosphorylation (6) subchapters (I – IV)

Harpers Illustrated Biochemistry chapters:

Enzymes: Mechanism of Action (7)

Enzymes: Kinetics (8)

Enzymes: Regulation of Activities (9)

Bioenergetics: The Role of ATP (11)

Lecture and seminar:

Examples of drugs as inhibitors – aspirin, ibuprofen, acetylcholinesterase inhibitors, methotrexate, trimetoprim, beta-lactam antibiotics. Use of enzymes in treatment. Use of enzymes in clinical diagnostics.

28.10.2026

Vitamins and trace elements

Required lecture:

Harpers Illustrated Biochemistry chapters:

Micronutrients: Vitamins & Minerals (44)
Plasma Proteins & Immunoglobulins (52)

Denise R. Ferrier "Biochemistry” chapters:

Vitamins (28)

Antivitamins and clinical diagnostics of vitamins B6, B9, B12  (discussed on lecture and seminar)

4.11.2026

 Reactive oxygen species, alcohols and drugs. 

18.11.2026

Colloquium 1 will commence on the 18 th of November  (from topic "Introduction to biochemistry"  to "ROS, alcohols and drugs")

25.11.2026

 Hormones and cytokines 

Required lecture:

Harpers Illustrated Biochemistry chapters:

Membranes: Structure and Function (40)

The Diversity of the Endocrine System (41)

Hormone Action & Signal Transduction (42)

Biosynthesis of Fatty Acid & Eicosanoids (23) subchapter Eicosanoids

Muscle & the Cytoskeleton (51) subchapter Nitric Oxide (NO)

Denise R. Ferrier "Biochemistry” chapters:

Complex lipid metabolism (17) subchapter (VIII) Prostaglandins and Related Compounds

Cytokines and growth factors - discussed on lecture and seminar

2.12.2026

 Carbohydrates and diabetes 

 Required lecture:

Denise R. Ferrier "Biochemistry” chapters:

Gluconeogenesis (10)

Glycogen Metabolism (11)

Pentose Phosphate Pathway and NADPH (13)

Glycosaminoglycans, Proteoglycans, and Glycoproteins (14)

Diabetes Mellitus (25)

Harpers Illustrated Biochemistry chapters:

Metabolism of Glycogen (18)

Gluconeogenesis & the Control of Blood Glucose (19)

The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism (20)

Lecture and seminar:

Carbohydrates in fasting and fed state

Glycogen storage diseases

9.12.2026

Lipids and steroids 

 Required lecture:

 Denise R. Ferrier "Biochemistry”:

Chapter 15: Metabolism of Dietary Lipids

Chapter 16: Fatty Acid, Triacylglycerol, and Ketone Body Metabolism

Chapter 17: Phospholipid, Glycosphingolipid, and Eicosanoid Metabolism

Chapter 18: Cholesterol, Lipoprotein and Steroid Metabolism

Harpers Illustrated Biochemistry:

Chapter 22: Oxidation of Fatty Acids: Ketogenesis

Chapter 23: Biosynthesis of Fatty Acids & Eicosanoids

Chapter 24: Metabolism of Acylglycerols& Sphingolipids

Chapter 25: Lipid Transport & Storage

Chapter 26: Cholesterol Synthesis, Transport, & Excretion

16.12.2026

14th of December - Colloqium II - from Hormones and cytokines to Lipids and steroids (Lab room)

Biochemistry of physical exertion - lecture and seminar 16th of December

 13.01.2027 

Purines, pyrimidines, porphyrins

Required lecture

Harpers Illustrated Biochemistry chapters:

Porphyrins & Bile Pigments (31)

Nucleotides (32)

Metabolism of Purine & Pyrimidine Nucleotides (33)

Denise R. Ferrier "Biochemistry” chapters:

Conversion of Amino Acids to Specialized Products (21) subchapter (II) Porphyrin Metabolism

Nucleotide Metabolism (22)

20.01.2027

Amino acids

Required lecture:

Harpers Illustrated Biochemistry chapters:

Amino Acids & Peptides (3)
Biosynthesis of the Nutritionally Nonessential Amino Acids (27)
Catabolism of Proteins & of Amino Acid Nitrogen (28)
Catabolism of the Carbon Skeletons of amino acids (29)

Denise R. Ferrier "Biochemistry” chapters:

Amino Acids (1)
Amino Acids: Disposal of Nitrogen (19)
Amino Acid Degradation and Synthesis (20)

27.01.2027

Integration of metabolism

 The final exam from Biochemistry V will be on the .......................

The Biochemistry final exam